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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF11
All Species:
17.88
Human Site:
T585
Identified Species:
43.7
UniProt:
O15085
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15085
NP_055599.1
1522
167704
T585
Y
D
A
P
E
P
G
T
Q
R
L
S
T
G
S
Chimpanzee
Pan troglodytes
XP_001167782
1522
167643
T585
Y
D
A
P
E
P
G
T
Q
R
L
S
T
G
S
Rhesus Macaque
Macaca mulatta
XP_001116835
1522
167570
T585
Y
D
A
P
E
P
G
T
Q
R
L
S
T
G
S
Dog
Lupus familis
XP_547523
1545
170397
T627
Y
D
A
P
E
P
G
T
Q
R
L
S
T
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4H2
1543
172304
E639
T
P
S
S
V
S
P
E
P
Q
D
P
A
K
L
Rat
Rattus norvegicus
Q9ES67
1527
168515
T593
Y
D
V
P
E
P
G
T
Q
R
L
S
T
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505606
1628
182548
E694
S
P
S
S
V
S
P
E
P
S
D
S
A
K
L
Chicken
Gallus gallus
XP_423659
1337
148636
K478
S
L
F
Q
D
L
G
K
L
K
S
R
P
A
H
Frog
Xenopus laevis
NP_001082763
1450
164220
P586
K
V
K
R
R
G
F
P
S
I
L
A
P
Q
R
Zebra Danio
Brachydanio rerio
NP_001027010
1417
157480
I546
R
N
P
I
L
K
Y
I
G
K
P
R
S
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.7
84.9
N.A.
30.9
83.6
N.A.
30.8
62.5
31.6
43.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.4
89.3
N.A.
49
89.4
N.A.
46.8
69.7
50
59.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
0
93.3
N.A.
6.6
6.6
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
13.3
93.3
N.A.
13.3
20
13.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
40
0
0
0
0
0
0
0
0
10
20
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
50
0
0
10
0
0
0
0
0
20
0
0
0
0
% D
% Glu:
0
0
0
0
50
0
0
20
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
60
0
10
0
0
0
0
50
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% I
% Lys:
10
0
10
0
0
10
0
10
0
20
0
0
0
20
0
% K
% Leu:
0
10
0
0
10
10
0
0
10
0
60
0
0
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
20
10
50
0
50
20
10
20
0
10
10
20
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
50
10
0
0
0
10
0
% Q
% Arg:
10
0
0
10
10
0
0
0
0
50
0
20
0
0
10
% R
% Ser:
20
0
20
20
0
20
0
0
10
10
10
60
10
0
60
% S
% Thr:
10
0
0
0
0
0
0
50
0
0
0
0
50
10
0
% T
% Val:
0
10
10
0
20
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
50
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _